Psychedelics and the Mystical Experience

What is it about psychedelics such as psilocybin, mescaline, LSD, DMT and others that can potentially facilitate transformative mystical experiences in some people?

https://medium.com/@thebubblerule/psychedelics-and-the-mystical-experience-de8b45f5a2ab?sk=7f00efc68b300dc012a5b548fe7e85e3